China experts found new molecular anti swine fever virus ca1477

China experts found new anti CSFV molecular original title: Chinese experts found new anti swine fever virus molecular Xinhua news agency in Harbin on 25 February, (reporter Yan Rui) 25 reporters from the Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences was informed that the researchers found an anti HCV activity of interferon stimulated gene guanylate binding protein 1 ", and expounds its antiviral mechanism. Classical swine fever (CSFV) is a highly contagious porcine infectious disease, which has a rapid spread and a high mortality rate. It can bring billions of dollars to the pig industry in China every year. It is listed in the list of notifiable animal diseases by the world animal health organization. China is listed as one of the priority animal diseases in the national plan for the prevention and control of animal diseases in the medium and long term. According to the Institute of infectious diseases of swine Kazakhstan animal innovation team of Dr. Li Lianfeng introduction, interferon stimulated gene, is a kind of molecular effect make host antiviral effects, target invasion, shelling, virion release virus replication cycle link. Blocking one of the links can inhibit the virus’s survival in the body. The team’s research starts with this. In a number of candidate genes for interferon stimulated genes, the team screened through high-throughput screening, and ultimately confirmed that "guanine nucleotide binding protein 1" is the anti interferon gene of classical swine fever virus. Chou Huaji, chief scientist researcher team explained that the molecules exert antiviral effect mainly depends on the activity of GTPase, and it is using its own classical swine fever virus NS5A protein and interferon stimulated gene interaction, inhibit the activity of GTPase, and then interfere with the GTP binding protein 1 antiviral function. Experts say the findings help to understand the host antiviral mechanism and provide clues for revealing the possibility of CSFV escaping host antiviral strategies. Combined antiviral interferon stimulated gene research has important significance for the innovation of swine fever prevention and control strategies to provide a reference for the study of antiviral and Flaviviridae CSFV other members. The results have been published online in the International Journal of Virology Journal of Virology. Editor in chief: Zhang Chun SN182

中国专家发现新抗猪瘟病毒分子   原标题:中国专家发现新的抗猪瘟病毒分子   新华社哈尔滨2月25日电(记者闫睿) 记者25日从中国农业科学院哈尔滨兽医研究所获悉,该所研究人员发现了一个可抗猪瘟病毒活性的干扰素刺激基因“鸟苷酸结合蛋白1”,并阐明了其抗病毒机制。   猪瘟是一种高度接触性猪传染病,传播快、致死率高,每年给我国养猪业带来的损失可达数十亿元,被世界动物卫生组织列入须申报的动物疫病名录。我国在《国家中长期动物疫病防治规划》中将其列为优先防治的一类动物疫病。   据哈兽研所猪烈性传染病创新团队李连峰博士介绍,干扰素刺激基因,是使得宿主发挥抗病毒作用的一类效应分子,可靶向侵入、脱壳、病毒粒子释放等病毒复制周期环节。阻断其中某一环节,即可抑制病毒在机体内的存活。该团队的研究即以此入手。   在获得的多个干扰素刺激基因候选分子中,团队通过高通量筛选鉴定,最终证实“鸟苷酸结合蛋白1”为抗猪瘟病毒的干扰素刺激基因。   团队首席科学家仇华吉研究员解释说,该分子发挥抗病毒作用主要依赖其GTPase活性,而猪瘟病毒恰是利用自身NS5A蛋白与干扰素刺激基因相互作用,抑制后者的GTPase活性,进而干扰“鸟苷酸结合蛋白1”的抗病毒功能。   专家说,此发现有助于深入了解宿主抗病毒机理,也为揭示猪瘟病毒逃避宿主抗病毒策略提供了线索。结合抗病毒干扰素刺激基因开展研究,对创新猪瘟防控策略具有重要意义,并为猪瘟病毒所在黄病毒科其他成员的抗病毒研究提供了参考。   此研究结果已在国际著名病毒学杂志《Journal of Virology》上在线发表。 责任编辑:张淳 SN182相关的主题文章: